ABSTRACT
@#Objective To observe the effects of ginsenoside Rb1 pretreatment on spinal cord ischemia-reperfusion injury in rats, and to explore the possible mitochondrial mechanism of ginsenoside Rb1 against ischemia-reperfusion injury. Methods The spinal cord ischemia-reperfusion injury model was established. The rats were randomly divided into sham operation group (n=12), ischemia-reperfusion group (n=12) and drug group (n=12). The drug group received gin-senoside Rb1 peritoneal injection with 10 mg/kg, 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively, 30 minutes be-fore modeling and once a day after modeling. After 48 hours of reperfusion, the BBB score was tested, the levels of superoxide dismutase (SOD) and malonaldehyde (MDA) in the serum and spinal cord tissue, and the cyto-chrome C oxidase (COX) activity in spinal cord tissue were detected. Results Compared with the ischemia-reperfusion group, the BBB score increased (P<0.05), the SOD level increased, and the MDA level decreased both in serum and spinal cord tissue, the activity of COX increased in the spinal cord tissue (P<0.05). All the indexes were dose-dependent, however, no difference was found between 40 mg/kg and 80 mg/kg. Conclusion Ginsenoside Rb1 can inhibit oxidative stress induced by spinal cord ischemia-reperfusion injury in rats by inhibiting mitochondrial damage. The protective effect of ginsenoside Rb1 on the spinal cord ischemia-reperfu- sion injury is dose-dependent during 10 to 40 mg/kg dose.
ABSTRACT
Objective To compare the postoperative imaging anatomical parameters and the related perioperative parameters of continuous double-gap cervical spondylotic myelopathy patients who underwent anterior cervical disectomy and fusion (ACDF)or anterior cervical corpectomy and fusion (ACCF)and ACDF so as to learn about the clinical effects of the two methods.Methods We included 5 1 patients in ACDF group (male∶female ratio=32∶19;mean age 56.3±29.4 years),and 47 patients (male∶female ratio=35∶12;mean age 49.1±22.8 years)in ACCF group.We measured the sex ratio,mean age,average length of hospital stay,mean operative time, and average intraoperative blood loss in ACDF group and ACCF group.The patients were followed up at six months,1 year,and 2 years after operation.The JOA score and imaging parameters were recorded for statistical analysis by SPSS 19.0.Results Patients in ACDF group had shorter operative time,less operative bleeding and shorter hospitalization duration than those in ACCF group.There was no significant difference in postoperative JOA score between ACDF and ACCF group.Patients in ACDF group had better imaging indexes than those in ACCF group.Conclusion ACDF has better screening efficacy than ACCF in treatment of continuous double-gap cervical disc herniation of cervical spondylotic myelopathy.